090 Podoplanin in peritumoral keratinocytes mediates dermal invasion in extramammary Paget's disease

Pagets Disease Of The Nipple

Extramammary Paget's disease in prostate.

Received October 2008 Accepted February 2009 INTRODUCTION Extramammary Paget’s disease is a condition morphologically similar to Paget’s disease in the breast, but occurs outside the breast. It is an uncommon condition as compared to its mammary counterpart. It most commonly affects the vulva, less commonly the male genital area or the perianal area.(1,2) To the best of our knowledge, extramamm...

Pagets disease of uncertain origin: case report

BACKGROUND Pagets disease of the nipple presents as an eczematous lesion, occurs in 1 - 4% of all female breast carcinoma cases and is invariably associated with underlying malignancy either overt or occult. The majority of these cases are invasive disease although 40-45% are associated with DCIS. CASE PRESENTATION A 39 year old lady presented to our unit with a palpable lump in the right bre...

Extramammary Perianal Paget's Disease

Perianal Paget's disease is a rare malignancy. It is rarely isolated and often associated with an underlying adenocarcinoma. It usually presents with anal itchiness and discomfort and can be misdiagnosed as hemorrhoids. Once the diagnosis of perianal Paget's disease is granted, extensive work-up to find an underlying primary malignancy is crucial. Surgery is the standard modality of treatment o...

Extramammary Paget’s disease

Extramammary Paget’s disease is an uncommon cutaneous adenocarcinoma, characterized by glandular differentiation and an insidious course. The condition may or may not be associated with an underlying adnexal or visceral malignancy. Because of its rarity, the pathogenesis is unclear, and standardization of treatment is lacking. The diagnosis is made histopathologically, and management is based o...